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Thursday, October 18, 2018 at 1.00 pm . Spine to nucleus signal in health and disease.

As part of the activities of the Interdepartmental Center for Neurosciences and Neurotechnologies (CfNN) and the PhD Program in Neuroscience, on Thursday, October 18, 2018 at 1.00 pm in the room H1.1, MO 15, via Campi 287., Prof. Monica Di Luca, from the Department of Pharmacological and Biomolecular Sciences of the University of Milan, will hold a seminar entitled "Spine to nucleus signal in health and disease".

The participation of teachers, researchers and students is welcome.

The Director of CfNN and PhD in Neurosciences

Michele Zoli

Abstract: Among the cellular processes required for modifications of dendritic spines, synapse-to-nucleus communication plays a key role in the regulation of the long-term structural changes correlated to regulation of de novo transcription which grantees protein synthesis. Multiple signalling pathways arising from dendritic spines converge to the nucleus regulating the expression of genes associated with changes of synapto-dendritic inputs. In particular, synapses, dendrites and nuclei are connected by bidirectional communication mechanisms that enable information transfer encoded by macromolecules. The talk will address novel pathways of synapse-to-nucleus communication both in health and disease.